A Review on Bioreactor Technology Assisted Plant Suspension Culture

Main Article Content

Renugaa Su
M. Sujarani
P. Shalini
N. Prabhu

Abstract

This review is related to bioreactors for plant suspension culture and its products. Bioreactor plays an important role in bioprocess engineering. The core of bioprocessing technology is the bioreactor. A bioreactor is basically a device in which the organisms are cultivated and helps in production of desired products in a contained environment. Bioreactors are usually a containment which provides optimal condition for microorganisms in order to produce desired products. In this review, the bioreactor’s principle, working and its types are discussed. Enclosed by unit operations that carry out physical changes for medium preparation and recovery of products, the reactor is where the major chemical and biochemical transformations occur. In many bioprocess, characteristic of the reaction determined to a large extent the economic feasibility of the project. The integration of biosynthesis and separation is considered as a possible approach towards more efficient plant cell and tissue culture. In this review article, the aspects of bioprocess engineering for plant suspension culture and its products, bioreactor types, optimized strategies for production of secondary metabolites also and its industrial applications.

Keywords:
Bioreactor, secondary metabolite production, industrial applications

Article Details

How to Cite
Su, R., Sujarani, M., Shalini, P., & Prabhu, N. (2019). A Review on Bioreactor Technology Assisted Plant Suspension Culture. Asian Journal of Biotechnology and Bioresource Technology, 5(3), 1-13. https://doi.org/10.9734/ajb2t/2019/v5i330062
Section
Review Article

References

Sajc L, Grubisic D, Novakovic GV. Bioreactors for plant engineering: An outlook for further research. Biochem. Eng. 2000;4:89999.

Miguel G. Acedos, Andrea Hermida, Emilio Gomez, Victoria E. Santos, and Felix Garcia-Ochoa, Effects of fluid-dynamic conditions in Shimwellia blattae (p424IbPSO) cultures in stirred tank bioreactors: Hydrodynamic stress and change of metabolic routes by oxygen availability. Biochemical Engineering Journal; 2016.

Panda AK, Mishra S, Bisaria VS, Bhojwani S. Plant cell reactors - a perspective. Enz. Microbial Technol., II. 1989;386-397.

Sajc L, Kovacevic N, Grubisic D , Vunjak- Novakovic G. Frangula species: in vitro culture and the production of anthraquinones, in: Bajaj (Ed.) YPS, Biotechnology in Agriculture and Forestry. Medicinal and Aromatic Plants XI, Springer, Berlin, Heidelberg. 1998;43: 157–176.

Books: Biotechnology, Satya Narayana U. Rader RA. Expression for process and product improvement. Bioprocess; 2008.

Roberts SC, Nail M, Gibson DM, Shuler ML, A simple method for enhancing paclitaxel release from Taxus Canadensis cell suspension cultures utilizing cell wall digesting enzymes. Plant Cell Rep 21. 2003;1217-1220

Applikon biotechnology. AppliFlex: Building a single-use technology platform; 2015.

Chatterjee C, Correl Weathers P, Wyslouzil BE, Walce DB. Simplified acoustic mist bioreactor. Worcester Polytechnic Institute Biotechnology Techniques. 1997;11(3):155-158.

Ross I, Medicinal Plants of the World Volume 3 Chemical Constituents, Traditional and Modern Medicinal Uses. 2005;272-273.

R Eibl D Eibl, Pörtner R , Catapano G, Czermak P. Cell and tissue reaction engineering first edition, Berlin: Springer Dordrecht Heidelberg; 2009.

De Dobbeleer C, Cloutier M, Fouilland M, Legros R, Jolicoeur M, A high-rate perfusion bioreactor for plant cells. Biotechnol Bioeng. 2006;95:1126–1137.

Eibl R, Eibl D. Single-use technology in biopharmaceutical manufacture. First edition. Hoboken, New Jersey: Wiley. Bronnenmeier R, Märkl H, Hydrodynamic stress capacity of microorganisms, Biotechnol. Bioeng. 2011;24:553–578.

Märkl H, Bronnenmeier R, Wittek B. The resistance of microorganisms to hydrodynamic stress, Int Chem Eng. 1991; 185–196.

Eibl R, Kaiser S, Lomb riser R, Eibl D. Disposable bioreactors: The current state of the art and recommended applications in biotechnology. Apply Microbial Biotechnol. 2006;6:41–49.

Panda AK, Mishra S, and Bisaria YS. Alkaloid production by plant cell suspension cultures of Holarrhena antidysenterica: I. Effect of major nutrients. Biotechnol. Bioeng. 1992;39:1043-1051.

Kato A, Kawazoe S, Soh Y. Viscosity of the broth of tobacco cells in suspension culture. J. Ferment. Technol. 1978;56: 224–228

Hell wig S, Drossard J, Twyman R, Fischer R. Plant cell cultures for the production of recombinant proteins Nature biotechnology. 2004;22(11):1425-1422.

Panda AK, Bisaria VS, and Mishra S. Alkaloid production by plant cell cultures of Holarrhena antidysenterica: II. Effect of precursor feeding and cultivation on stirred tank bioreactor. Biotechnol. Bioeng. 1992; 39:1052-1057.

Sowana DD, Williams DRG, Dunlop EH, Dally BB, O’Neill BK, Fletcher DF. Turbulent shear stress effects on plant cell suspension cultures, Chem. Eng. 2001;79: 867–875.

Klöckner W, Diederichs S, Busch J. Orbital shaken single-use bioreactors. Adv. Biochem Eng. Biotechnol, 2014;138:45–60.

Shuler ML. Strategies for improving productivity in plant cell, tissue and organ culture in bioreactors, in: Yoshida T, Tanner (Eds.) RD, Bio products and Bioprocesses, Springer, Berlin. 1993;2: 235–245.

Jaouen P, Vandanjon L, Quéméneur R. The shear stress of microalgal cell suspensions (Tetraselmis suecica) in tangential flow filtration systems: the role of pumps, Bioresour. Technol.1999;68:149–154.

Curtis WR, Emery AH, Plant cell suspension culture rheology, Biotechnol. 1982;425–442.

Van Gulik WM, ten Hoopen HJ, Heijnen JJ, The application of continuous culture for plant cell suspensions. Enzyme Microb Technol. 2003;28:796–805.

Brodzlius P, Nilsson K, Erul J Permeabilization of immobilized plant cells, resulting in release of intracellularly stored products with preserved cell viability. Appl Microbiol Biotechnol. 1983;17:275-280.

Freeman A, Woodley JM, Lilly MD In situ product removal as a tool for bioprocessing. Nat Biotech. 1993;11:1007-1012.

Malik S, Hossein Mirjalili M, Fett-Neto AG, Mazzafera P, Bonfill M. Living between two worlds: Two-phase culture systems for producing plant secondary metabolites. Crist Rev Biotechnol. 2013;33:1-22 57.

Talano MA, Oller AL, González PS, Agostino E. Hairy roots, their multiple applications and recent patents. Recent Pat Biotechnol., 2012;6:115-133.

Banerjee S, Singh S, Rahman LU Biotransformation studies using hairy root cultures. Biotechnol Adv. 2012;30:461-468.

Giri A, Dhingra V, Giri CC, Singh A, Ward OP and Narasu MLL Bio transformation’s using plant cells, organ cultures and enzyme systems: Current trends and future prospects. Biotechnol Adv. 2001;19 175-199.

Ishihara K, Hamada H, Hirata T, and Nakajima N, Biotransformation using plant cultured cells. J Mol Catal B Enzyme. 2003;23:145-170

Grech-Baran M, Sykłowska-Baranek K, Krajewska-Patan A, Wyrwał A, Pietrosiuk A. Biotransformation of cinnamyl alcohol to rosavins by non-transformed wild type and hairy root cultures of Rhodiola kirilowii. Biotechnol Lett. 2014;36:649-656.

Pauline M Doran. Bioprocess engineering principles-second edition; 2013.

Bronnenmeier R, Märkl H, Hydrodynamic stress capacity of microorganisms, Biotechnol. Bioeng. 1982;24:553–578.

Meijer JJ, tenHoopen HJG, vanGameren YM, Luyben KCAM, Libbenga KR. Effects of hydrodynamic stress on the growth of plant cells in batch and continuous culture. Enzyme Microbe. Technol. 1994;16:467–477.

HI taka Y, Takahashi Y, Kino Oka M, Taya M, Tone S. Culture of red beet hairy roots by considering variation in sensitivity of tip meristems to hydraulic stress, Biochem. Eng. 2000;6:16.

Endo T, Goodbody A, Misawa M. Alkaloid production in root and shoot cultures of Cathavanthus rosez. Planta Med. 1987; 53:479-482.

Dutta Gupta S and Ibaraki (eds.) Y. Plant Tissue Culture Engineering, springer. 2008;203–227.

Marchuk J C, Shear effects on suspended cells, Adv. Biochem. Eng. Biotechnol. 1991;44:65–95.

Bronnenmeier R, Märkl H, Hydrodynamic stress capacity of microorganisms, Biotechnol. Bioeng. 1982;24:553–578.

Jaouen Vandanjon L, Quéméneur F. The shear stress of microalgal cell suspensions (Tetraselmis suecica) in tangential flow filtration systems: the role of pumps, Bioresour. Technol. 1999;68:149–154.

Kurata H, Kawai A, Seki M, Furusaki S. Increased alkaloid production in a suspension culture of Coffea arabica cells using adsorption column for product removal. Bioeng. 1994;78:117–119.

Albertson PA. Partition of Cell Particles and Macromolecules, Wiley, New York; 1960.

Flygare S, Wikstrom P, Johansson G, Johansson G, Larsson PO. Magnetic aqueous two-phase separation in preparative applications, Enz. Microb. Technol. 1990;12:95–103.

Husted H, Johansson G, Tjerneld F. Aqueous two-phase separation systems. Bio separation. 1990;1:177–224.

Lukner M. Expression and control of secondary metabolism, in: E.A. Bell, B.V. Charlwood (Eds.), Encyclopedia of Plant Physiology, vol. 8, Secondary Plant Products, Springer, Berlin, Heidelberg, New York. 1980;48:22–63.

Lin PJ, Scholz A Krull R. Effect of volumetric power input by aeration and agitation on pellet morphology and product formation of Aspergillus niger, Biochem. Eng., Springer, Berlin. 1977;245–252.

Lidija Sajc, Dragan Grubisic, Gordana Vunjak-Novakovic. Bioreactors for plant engineering: An outlook for further research. 2000;4:89-99.

Wagner JF, Vogel Mann H, Barz W, Rein hard E, Zenk (Eds.) MH cultivation of plant tissue culture in bioreactors and formation of secondary metabolites, Springer, Berlin. 1977;245–252.

Barz W, Rein hard, Zenk E. Plant tissue culture and its biotechnology application, Springer, Berlin. 1977;245–252.

Adrià Calvet Pujol Fisiologia Vegetal, Plant cells and suitable bioreactors, Bio logia cellular Botanicals 4 d’abrildel; 2016.

Sajc L, et al. Biochemical Engineering Journal. 2000;91:89–99.

Regine Eibl, Dieter Eibl. Design and use of the wave bioreactor for plant cell culture; 2001.

Saurabh Chattopadhyay, Ashok K. Production of Podophyllotoxin by Plant Cell Cultures of Podophyllum hexandrum in Bioreactor; 2002.

Papoutsakis ET. Fluid-mechanical damage of animal cells in bioreactors. Trends Biotechnol.1991;94:27–437.